These scientific figures accompany a review article “Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis” in the JCI insight, published September 7, 2017. These are created to compare the molecular mechanism and the physiological differences of alcoholic steatohepatitis and nonalcoholic steatohepatitis. Read full article here.
The team sat down with the client to understand the background and the mechanism in which the client is hoping to depict in the figure. Here, we display the client sketches and instructions given during our initial consultation.
We first researched academic literatures to obtain deeper understanding of the numerous proteins that are to be drawn in the figure. By using the Protein Data Bank (PDB), we scraped data to understand the characteristics of each protein as well as how they appear different in their 3D structure.
Combining traditional and digital technique, a sketch is created to be reviewed by the client. We primarily focused on organizing the information in a more intuitive flow. The background represents a bloodflow inside the liver. The inset shows the molecular mechanism in a steatohepatitic hepatocyte.
Using the information collected during the research phase, we reconstructed a unique pseudo-3D look of each protein. Here, we list the 2D assets built to be used in the final figure. The color red is provided to clarify the nucks and cranies however the color of each protein hasn't been decided at this point.