CRISPR/Cas9 loaded lipid nanoparticle

CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles

This journal cover accompanies a paper “Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles.” published in the Advanced Healthcare Materials, March 2019. It depicts Cas9 delivery into an animal cell by lipidoid nanoparticles to promote genome editing. See the full publication here.

Step 1: Science download

We sat down to understand what the client envisioned in their journal cover. As well as reading the unpublished manuscript to understand the concept, a sketch is provided by the client to understand their concept.

Step 2: Sketches

Based on our initial deep-dive, we created several versions of the sketch that aligns with the client's view. We provided multiple versions that includes different components, such as a drug capsule and a human with IV, to find the right context to what the client is looking for.

Step 3: Asset building

3D visual assets have been built to provide a consistent look in the final image. Here, we used Cinema 4D and Zbrush to create an organic look of the neurons.

Step 6: Final touch

Finally, we made decisions on the small details that could be editable in Photoshop. Here, we showed the evolution to the final color scheme of the artwork.

Final Deliverable