Biased ligand of GPCR

Biased ligand of GPCR

This molecular landscape shows the accurate binding of a Carvedilol to the beta-1 adrenergic receptor, a G-protein coupled receptor (GPCR) that is expressed in the heart. This 3D still image is targeting the medical professional audience and communicates the mechanism of action of biased ligands, a current topic in pharmacology. The goal of this artwork is to create an accurate illustration to effectively communicate the science behind the topic. A storyboard was created based on primary literature. All molecules were created using Visual Molecular Dynamics (VMD), which creates a 3D model from a data in the Protein Data Bank (PDB). The size relationship with proteins with the lipid bilayer was measured using Orientations of Proteins in Membranes. The 7 helices of the GPCR were separated and color-coded using UniProt.

Final Deliverable


Project Details

  • Client :
    University of Illinois at Chicago
  • What We Did :
  • Tools Used :
    Photoshop, 3D Studio Max
  • Completed on :
    December 2015
  • Skills :
    3D sculpting
  • Audience :
    Healthcare Professionals